Orestis G. Andriotis PhD

Research Unit of Biomechanics

Function: Senior Scientist

Room Number: BE 02 07

Further affiliations: Austrian Cluster for Tissue Regeneration

email: orestis.andriotis@tuwien.ac.at

phone: +43 1 58801 31718

Office hours: Please send email


About me:

In 2008 I graduated with a Material Science degree from the University of Patras and soon after I completed my Ph.D. studies in biomechanics at the Bioengineering Research Group (University of Southampton). During my Ph.D. and the early years as a post-doc, I developed methods for the nanoscale and microscale characterization of biological tissues, and especially of individual collagen fibrils, by employing atomic force microscopy techniques.


Research:

My current research focuses on the spatiotemporal dynamics of collagen fibril degradation by matrix metalloproteinases through the combination of super-resolution fluorescence and atomic force microscopy (the COSiMA project funded by WWTF), the nano- and microscale mechanics of biological tissues in health and disease, and developing tools and methods for the mechanical characterization of tissues, cells and cell clusters (spheroids and organoids).


Research Interests:

• Structure-function relationships of biological tissues and sub-cellular components
• Spatiotemporal degradation kinetics of collagen fibrils
• Nano- and micromechanics of biological tissues and materials
• Method development for nanomechanical assessment
• Nano- and microscale structural-mechanical alterations in pathologies affecting extracellular matrix components
• Atomic force microscopy as a tool for mechanical assessment